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Event Details

Open for registration

Global Neuro Webinar—Biomarkers in Traumatic Brain Injury

Time: Dec 2: 17:30 PM-19:30 PM (CET);
Dec 2: 11:30 AM-1:30 PM (EST);
Dec 2: 8:30 AM-10:30 PM (PST);

  • 02 December 2021
  • Andras Büki

András Büki, University of Pécs, Hungary, Stefania Mondello, University of Messina, Italy Ava Puccio, University of Pittsburgh, USA Matej Orešič, Örebro University, Sweden Endre Czeiter, University of Pécs, Hungary

Course Chairs
  • Andras Büki
     
International Faculty
Format
Online Education
Content
Lectures, Interactive case discussion, Q&A session
Target audience

This Global Neuro webinar has been developed for residents, intensivists, nurses, surgeons, and other physicians who are interested in the management of severe Traumatic Brain Injury, complex patient care, clinical research, and an interdisciplinary approach.

Languages
English

This webinar is aimed to provide a comprehensive view on the role of biomarkers in the field of care for traumatic brain injury. The primary goal is to focus on translational aspects, detailing recent observations and study results that could improve all aspects of patient care from diagnostics to prognosis, through care paths of the prehospital, hospital and rehabilitation phase.  

Agenda

TIME AGENDA

FACULTY

17:30-17:35

 Welcome and webinar objectives

András Büki 

17:35-17:55

 The role of TBI Biomarkers in the prediction of CT positivity following TBI – Background and results from CENTER-TBI study

Endre Czeiter 

17:55-18:15

 The role of TBI Biomarkers in the prediction of CT positivity following TBI – Results from TRACK-TBI study and iSTAT pivotal trial 

Ava Puccio

18:15-18:35

 The role of lipidomics and metabolomics in the early diagnosis of Traumatic Brain Injury 

Matej Orešič 

18:35-19:20

 Q&A Session and Panel Discussion

Stefania Mondello / All 

19:20-19:30

 Closing remarks

András Büki 

 

Recommended Articles

I. Clinical research/studies in field of TBI in general (containing some baselines about biomarkers):

Maas AIR, Menon DK, Adelson PD, Andelic N, Bell MJ, Belli A, Bragge P, Brazinova A, Büki A, Chesnut RM, Citerio G, Coburn M, Cooper DJ, Crowder AT, Czeiter E, Czosnyka M, Diaz-Arrastia R, Dreier JP, Duhaime AC, Ercole A, van Essen TA, Feigin VL, Gao G, Giacino J, Gonzalez-Lara LE, Gruen RL, Gupta D, Hartings JA, Hill S, Jiang JY, Ketharanathan N, Kompanje EJO, Lanyon L, Laureys S, Lecky F, Levin H, Lingsma HF, Maegele M, Majdan M, Manley G, Marsteller J, Mascia L, McFadyen C, Mondello S, Newcombe V, Palotie A, Parizel PM, Peul W, Piercy J, Polinder S, Puybasset L, Rasmussen TE, Rossaint R, Smielewski P, Söderberg J, Stanworth SJ, Stein MB, von Steinbüchel N, Stewart W, Steyerberg EW, Stocchetti N, Synnot A, Te Ao B, Tenovuo O, Theadom A, Tibboel D, Videtta W, Wang KKW, Williams WH, Wilson L, Yaffe K; InTBIR Participants and Investigators. Traumatic brain injury: integrated approaches to improve prevention, clinical care, and research. Lancet Neurol. 2017 Dec;16(12):987-1048. doi: 10.1016/S1474-4422(17)30371-X.

II. Biomarkers and metabolomics in TBI:

1. Orešič M, Posti JP, Kamstrup-Nielsen MH, Takala RSK, Lingsma HF, Mattila I, Jäntti S, Katila AJ, Carpenter KLH, Ala-Seppälä H, Kyllönen A, Maanpää HR, Tallus J, Coles JP, Heino I, Frantzén J, Hutchinson PJ, Menon DK, Tenovuo O, Hyötyläinen T. Human Serum Metabolites Associate With Severity and Patient Outcomes in Traumatic Brain Injury. EBioMedicine. 2016 Oct;12:118-126. doi: 10.1016/j.ebiom.2016.07.015

2. Wang KK, Yang Z, Zhu T, Shi Y, Rubenstein R, Tyndall JA, Manley GT. An update on diagnostic and prognostic biomarkers for traumatic brain injury. Expert Rev Mol Diagn. 2018 Feb;18(2):165-180. doi: 10.1080/14737159.2018.1428089.

3. Mondello S, Sorinola A, Czeiter E, Vámos Z, Amrein K, Synnot A, Donoghue E, Sándor J, Wang KKW, Diaz-Arrastia R, Steyerberg EW, Menon DK, Maas AIR, Buki A. Blood-Based Protein Biomarkers for the Management of Traumatic Brain Injuries in Adults Presenting to Emergency Departments with Mild Brain Injury: A Living Systematic Review and Meta-Analysis. J Neurotrauma. 2021 Apr 15;38(8):1086-1106. doi: 10.1089/neu.2017.5182.

4. Yue JK, Yuh EL, Korley FK, Winkler EA, Sun X, Puffer RC, Deng H, Choy W, Chandra A, Taylor SR, Ferguson AR, Huie JR, Rabinowitz M, Puccio AM, Mukherjee P, Vassar MJ, Wang KKW, Diaz-Arrastia R, Okonkwo DO, Jain S, Manley GT; TRACK-TBI Investigators. Association between plasma GFAP concentrations and MRI abnormalities in patients with CT-negative traumatic brain injury in the TRACK-TBI cohort: a prospective multicentre study. Lancet Neurol. 2019 Oct;18(10):953-961. doi: 10.1016/S1474-4422(19)30282-0.

5. Czeiter E, Amrein K, Gravesteijn BY, Lecky F, Menon DK, Mondello S, Newcombe VFJ, Richter S, Steyerberg EW, Vyvere TV, Verheyden J, Xu H, Yang Z, Maas AIR, Wang KKW, Büki A; CENTER-TBI Participants and Investigators. Blood biomarkers on admission in acute traumatic brain injury: Relations to severity, CT findings and care path in the CENTER-TBI study. EBioMedicine. 2020 Jun;56:102785. doi: 10.1016/j.ebiom.2020.102785.

6. Okonkwo DO, Puffer RC, Puccio AM, Yuh EL, Yue JK, Diaz-Arrastia R, Korley FK, Wang KKW, Sun X, Taylor SR, Mukherjee P, Markowitz AJ, Jain S, Manley GT; Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI) Investigators. Point-of-Care Platform Blood Biomarker Testing of Glial Fibrillary Acidic Protein versus S100 Calcium-Binding Protein B for Prediction of Traumatic Brain Injuries: A Transforming Research and Clinical Knowledge in Traumatic Brain Injury Study. J Neurotrauma. 2020 Dec 1;37(23):2460-2467. doi: 10.1089/neu.2020.7140.

7. Posti JP, Dickens AM, Orešič M, Hyötyläinen T, Tenovuo O. Metabolomics Profiling As a Diagnostic Tool in Severe Traumatic Brain Injury. Front Neurol. 2017 Aug 18;8:398. doi: 10.3389/fneur.2017.00398.

8. Dickens AM, Posti JP, Takala RSK, Ala-Seppälä H, Mattila I, Coles JP, Frantzén J, Hutchinson PJ, Katila AJ, Kyllönen A, Maanpää HR, Newcombe V, Outtrim J, Tallus J, Carpenter KLH, Menon DK, Hyötyläinen T, Tenovuo O, Orešic M. Serum Metabolites Associated with Computed Tomography Findings after Traumatic Brain Injury. J Neurotrauma. 2018 Nov 15;35(22):2673-2683. doi: 10.1089/neu.2017.5272.

III. For more detailed insights to the topic:

Wu AHB, Peacock WF. Biomarkers for Traumatic Brain Injury: Elsevier Science; 2020.

This Global Neuro Neurotrauma Webinar covers recent advances in the field from all over the world and will support participants in managing traumatic brain injury and making proper decisions in complex cases.

By completing this webinar, participants will be better able to

  • Define and stratify biomarkers of traumatic brain injury (K).
  • Apply biomarkers in the care path for TBI (S).
  • Critically assess biomarker related research communications (A, S).

Global Neuro, Linda Domeisen
Phone: +41768240488, Email: linda.domeisen@globalneuro.org

Seats
1000
   
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